Loss of righting reflex assay results for global and conditional α1 GABAA-R subunit knockout mice
Values in parentheses indicate the number of male and female mice, respectively.
| Genotype | n | Anesthetic | EC50 |
|---|---|---|---|
| atm% ± S.E. | |||
| Control | 17 (9/7) | Halothane | 0.82 ± 0.02 |
| Global KO | 19 (14/5) | 0.98 ± 0.02* | |
| Control | 18 (9/9) | Isoflurane | 0.80 ± 0.01 |
| Global KO | 18 (14/4) | 0.80 ± 0.02 | |
| Control | 12 (6/6) | Halothane | 0.94 ± 0.03 |
| Conditional KO | 10 (5/5) | 0.92 ± 0.03 | |
| Control | 11 (5/6) | Isoflurane | 0.79 ± 0.02 |
| Conditional KO | 11 (5/6) | 0.76 ± 0.03 |
KO, knockout.
↵* P < 0.0001.