TABLE 1

Structures of somatostatin analogs

Agonists
    SS-14 Ala-Gly-cyclo-[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys]
    SS-28 Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-(SS-14)
    Cortistatin-17 Asp-Arg-Met-Pro-cyclo-[Cys-Arg-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys]Lys
    Vapreotide d-Phe-cyclo-[Cys-Tyr-d-Trp-Lys-Val-Cys]-Trp-NH2
    Octreotide d-Phe-cyclo-[Cys-Phe-d-Trp-Lys-Thr-Cys]-Thr-ol
    [Tyr3]Octreotide d-Phe-cyclo-[Cys-Tyr-d-Trp-Lys-Thr-Cys]-Thr-ol
    KE108 Tyr-cyclo-[d-Dab-Arg-Phe-Phe-d-Trp-Lys-Thr-Phe]
    SOM230 cyclo-[Dec-HyPro-Phg-d-Trp-Lys-Tyr(Bzl)-Phe]
Antagonists
    Coy-14 Cpa-cyclo-[d-Cys-Tyr-d-Trp-N-methyl-Lys-Thr-Cys]-Nal-NH2
    CYN-154806 Acetyl-4NO2-Phe-cyclo-[d-Cys-Tyr-d-Trp-Lys-Thr-Cys]-d-Tyr-NH2
  • Cpa, 3-(4-chlorophenyl)alanine; Dab, diaminobutyric acid; Dec, diaminoethylcarbamoyl; HyPro, hydroxyproline; Nal, 3-(2-naphthyl)alanine; Phg, phenylglycine; Tyr(Bzl), (4-O-benzyl)-l-tyrosine.