TABLE 7

Common (>1%) FMO3 upstream haplotypes

Haplotype Mean Frequency
Number Nucleotide Changes Hispanic American African American White
(n = 402) (n = 402) (n = 400)
1 Reference sequence 54.1 ± 0.2 68.9 ± 0.6a 55.4 ± 0.7
2 −2650C>G, −2543T>A, −2177G>C 28.9 ± 0.2a 10.9 ± 0.4a 6.3 ± 0.4a
3 −2650C>G 15.3 ± 0.2a 8.3 ± 0.5a 19.8 ± 0.7a
4 −2650C>G, −2543T>A Rb 4.7 ± 0.4 4.3 ± 0.6
8 −2589C>T, −2106G>A R Nc 3.7 ± 0.3
11 −2543T>A N 2.9 ± 0.4a 9.2 ± 0.6a
15 −2106G>A, −1961T>C N 1.5 ± 0.3 N

  • ↵ a Significantly different from other population groups, P < 0.001.

  • ↵ b Haplotype inferred, but rare (<1%).

  • ↵ c Haplotype not inferred.