Effect of 2 mM Ca2+ on the peak 1 mM acetylcholine response at -50 mV Values are presented as mean ± S.E.M.
| Receptor | Number of Oocytes | Ca2+-Induced Change in Acetylcholine Response |
|---|---|---|
| % | ||
| α4β2 | 4 | 310 ± 30 |
| α4(E180Q)β2 | 4 | –10.0 ± 0.4 |
| α4β2(E177Q) | 8 | 410 ± 30* |
| α4(S252F)β2 | 4 | 30 ± 10* |
| α4(S256L)β2 | 4 | 40 ± 4* |
| α4(+L264)β2 | 4 | 10 ± 2* |
| α4β2(V262L) | 4 | –20 ± 4* |
| α4β2(V262M) | 5 | 40 ± 4* |
| α4(E245Q)β2 | 5 | 90 ± 30* |
| α4(E266Q)β2 | 4 | 300 ± 10 |
| α4(E180Q:S252F)β2 | 8 | –10 ± 4 |
| α4(E180Q:S256L)β2 | 5 | 10 ± 4† |
| α4(E180Q:+L264)β2 | 4 | –50 ± 2† |
| α4(E180Q)β2(V262L) | 6 | –30 ± 5† |
| α4(E180Q)β2(V262M) | 4 | –40 ± 6† |
| α4(E245Q)β2(V262L) | 5 | –50 ± 10 |
| α4(E266Q)β2(V262L) | 4 | –40 ± 2 |