TABLE 1

Kinetic parameter estimates for flurbiprofen 4 ′-hydroxylation in the presence of varying concentrations of benzbromarone

Data were fit to a two-site model (see eq. 1). Parameter estimates are reported as the estimate (mean ± S.E. of the estimate) resulting from nonlinear regression of the data. K_b, the binding constant for the effector; α, the change in K_m resulting from effector binding; and β, the change in V_m resulting from effector binding. An α value <1 indicates a decrease in K_m. A β value >1 indicates an increase in V_m, whereas a β value <1 indicates a decrease in V_m.