TABLE 1
In vitro potency and selectivity of LY518674: comparison with fenofibric acid
IC50 is the concentration of agonist required to displace 50% of the radiolabeled reference compound in an hPPAR α receptor binding assay. EC50 is the concentration of agonist producing 50% of maximum stimulation in hPPARα, mPPARα, hPPARγ, and hPPARδ contransfection assays. The difference in mouse and human EC50 values is due to the known species-related differences in the receptor affinity. Please note that the values in the last column (PPAR γ/PPARα), indicating selectivity, are from the IC50 for the two receptors.