Examples of structurally unrelated ion channels regulated by capsaicin and capsazepine
To avoid possible effects of TRPV1 receptors; the list is incomplete in that we focus on results obtained in cells in which the TRPV1 receptor has not bee n described. Furthermore, the examples chosen satisfy one or more of the following criteria: a) no activation of current by capsaicin or no change in resting membra ne potential; b) no description of activation of current or change in resting membrane potential by capsaicin; c) effects of capsa zepine similar to capsaicin; d) nonmam malian.
| Channel Type | Cell Type, Species | Capsaicin | Capsazepine | Criteria | Reference |
|---|---|---|---|---|---|
| μM | |||||
| Delayed rectifier K+ current | NG108-15 | 20 | 20 | b,c | Lo et al. (2003) |
| IK(erg) current | NG108-15 | 20 | b | Lo et al. (2003) | |
| L-type Ca2+ current | NG108-15 | 5 | 5 | b,c | Lo et al. (2003) |
| Slow/fast K+ current | Neuron, Xenopus laevis | 1-200 | 50 | b,c,d | Kuenzi and Dale (1996) |
| Ca2+ current | Neuron, Xenopus laevis | 1-200 | 50 | b,c,d | Kuenzi and Dale (1996) |
| Trans. outward K+ current | Myocyte, rat | 1-30 | a | Wu et al. (1996) | |
| Late outward K+ current | Myocyte, rat | 3-100 | a | Wu et al. (1996) | |
| Acetylcholine/adenosine, K+ current | Myocyte, rat | 10-300 | a | Wu et al. (1996) | |
| Voltage-dependent Na+ channel | Myocyte, rat | 0.4-4 | b | Milesi et al. (2001) | |
| Kv(1.1, 1.2, 1.3, 1.5, 3.1) | L929, B82, MEL | 20-200 | b | Grissmer et al. (1994) | |
| Nicotinic acetylcholine receptor | Pheochromocyte, rat | 1-30 | b | Nakazawa et al. (1994) | |
| CFTR | NIH3T3, CHO | 25-200 | a | Ai et al. (2004) | |
| ICRAC | Jurkat T-cell, human | 2-200 | 1-25 | a,c | Fischer et al. (2001) |
CFTR, cystic fibrosis transmembrane conductance regulator.