TABLE 2

CYP3A content and related activity in pediatric patients treated with barbiturates or steroids

Sample Age Treatment (Duration) Total CYP3A Protein CYP3A5 Protein Testosterone-6 β Hydroxylase
OD unit · mg protein −1 nmol · min−1 · mg protein−1
86 6 days PB (4 days) 1.28 (228) 0 0.281 (1873)
49 16 days PB (9 days) 1.06 (171) 0.015 0.053 (139)
77 3 months PB (3 days) 1.44 (212) 0.426 0.208 (371)
79 9 years Prednisone (1 year) 0.45 (79) 0 0.066 (55)
83 9 years PB (7 days) 1.38 (242) 0.009 0.305 (252)
  • PB, phenobarbital. Values in parentheses indicate the percentage of untreated samples in the same group of age.