The steady-state inactivation parameters of the WT, F656V, and F656M channels at 0, 5 and 135 mM [K+]o
| 0 mM [K+]o | 5 mM [K+]o | 135 mM [K+]o | |||||||
|---|---|---|---|---|---|---|---|---|---|
| V1/2 | k | n | V1/2 | k | n | V1/2 | k | n | |
| WT | −50.1 ± 2.2 | 20.1 ± 1.1 | 6 | −29.4 ± 1.4 | 20.6 ± 0.4 | 7 | −8.9 ± 1.8 | 19.2 ± 1.2 | 5 |
| F656V | −54.2 ± 4.1 | 25.2 ± 1.5 | 4 | −33.1 ± 3.1 | 22.1 ± 1.9 | 5 | −9.7 ± 2.9 | 25.1 ± 2.7 | 5 |
| F656M | −62.9 ± 2.9* | 21.6 ± 1.2 | 4 | −41.4 ± 1.6* | 20.9 ± 1.8 | 6 | −19.1 ± 2.6* | 19.1 ± 2.1 | 4 |
V1/2, voltage for half-maximal inactivation; k, slope factor; n, number of cells tested.
↵* P < 0.01.