Ligand | Ki Value | ANOVA | ||||
---|---|---|---|---|---|---|
mMOR-1 | mMOR-1B1 | mMOR-1B2 | mMOR-1B3 | mMOR-1B5 | ||
nM | ||||||
Morphine | 5.3 ± 2.0 | 5.3 ± 1.0 | 3.9 ± 0.4 | 1.5 ± 0.5 | 1.4 ± 0.6 | N.S. |
M6G | 5.2 ± 1.8 | 10.1 ± 1.6 | 8.4 ± 1.3 | 3.9 ± 1.3 | 5.2 ± 0.1 | N.S. |
DAMGO | 1.8 ± 0.5 | 1.4 ± 0.2 | 1.3 ± 0.1 | 1.8 ± 0.9 | 1.0 ± 0.3 | N.S. |
DADLE | 2.1 ± 0.3 | 9.0 ± 1.1 | 4.9 ± 0.7 | 1.9 ± 0.4 | 2.4 ± 0.4 | P < 0.001 |
DSLET | 12.5 ± 3.6 | 8.9 ± 1.1 | 22.1 ± 1.5 | 8.7 ± 1.8 | 11.5 ± 5.2 | P < 0.04 |
Naloxone | 4.3 ± 0.9 | 0.5 ± 0.3 | 1.3 ± 0.1 | 1.4 ± 0.5 | 0.6 ± 0.3 | N.S. |
Dynorphin A | 10.9 ± 0.5 | 14.6 ± 7.1 | 34.3 ± 18.4 | 8.7 ± 1.8 | 8.9 ± 2.3 | N.S. |
β-Endorphin | 10.8 ± 2.9 | 6.8 ± 3.2 | 4.9 ± 1.7 | 3.1 ± 1.4 | 5.7 ± 1.2 | N.S. |
Endomorphin 1 | 2.1 ± 0.8 | 10.8 ± 5.6 | 5.0 ± 1.8 | 3.2 ± 0.6 | 4.3 ± 0.8 | N.S. |
Endomorphin 2 | 4.2 ± 1.8 | 12.4 ± 1.5 | 8.4 ± 1.1 | 3.2 ± 0.8 | 10.6 ± 1.8 | P < 0.01 |
U50,488H | >500 | >500 | >500 | >500 | >500 | |
DPDPE | >500 | >500 | >500 | >500 | >500 |
N.S., not significant; DSLET, [D-Ser2, Leu5]enkephalin-Thr6.