TABLE 1

Effects of positive modulators on macroscopic properties of NR responses according to the kinetic mechanism used See Fig. 1a for control values for all rate constants.

Rate Single-Pulse Stimulation θ-Burst Stimulation Charge Ratio θB/SP
Rise Time Peak Po τdecay Charge Peak Po τdecay Charge
s –1 ms ms fC ms fC
Control 8.8 0.2 47 120 0.35 47 275 2.3
k + 85 10.1 0.19 45 110 0.35 45 272 2.5
k +1 600 5.1 0.42 120 550 0.52 111 800 1.5
k +2 2900 6.3 0.37 145 590 0.66 140 1114 1.9
k +3 12,500 8.3 0.38 140 590 0.7 139 1185 2.0
k +4 17,250 11.4 0.33 133 490 0.68 132 1053 2.1
k – 12 10.9 0.3 150 510 0.38 147 683 1.3
k –1 32 10.5 0.28 192 510 0.49 186 1019 2.0
k –2 522 8.5 0.33 150 530 0.64 148 1133 2.1
k –3 432 11.7 0.34 155 570 0.71 171 1393 2.4
k –4 132 11 0.32 135 500 0.67 167 1270 2.5

  • θB, θ-burst; SP, single pulse.