TABLE 2

Effects of negative modulators on kinetic parameters of NR macroscopic response according to the kinetic mechanism used See Fig. 1a for control values for all rate constants.

Rate Single-Pulse Stimulation θ-Burst Stimulation Charge Ratio θB/SP
Rise Time Peak Po τdecay Charge Peak Po τdecay Charge
s –1 ms ms fC ms fC
Control 8.8 0.2 47 118 0.35 47 278 2.4
k + 3.4 6.6 0.2 45 121 0.35 48 286 2.4
k +1 24 10.9 0.05 29 21 0.12 33 75 3.6
k +2 116 12.5 0.06 27 23 0.11 30 62 2.7
k +3 500 14.5 0.06 29 23 0.09 28 61 2.7
k +4 690 8.9 0.09 29 36 0.14 30 99 2.8
k – 300 8.9 0.09 28 33 0.21 28 181 5.5
k –1 800 8.1 0.09 21 21 0.13 19 70 3.3
k –2 13,050 9.7 0.06 25 22 0.11 25 62 2.8
k –3 10,800 9.7 0.06 26 21 0.09 25 61 2.9
k –4 3300 9.3 0.1 29 37 0.13 28 98 2.6

  • θB, θ-burst; SP, single pulse.