TABLE 1

Study design, serum cholesterol, and body weight after 5 weeks of treatment Mean body weight and serum cholesterol concentrations ± S.E.M. for five animals per group.

Group	Treatment	Body Weight	Serum Cholesterol
		g	mg/dl
Sham	Vehicle p.o.	285 ± 18	111 ± 8^*
Ovx	Vehicle p.o.	309 ± 9	123 ± 9
Ral	1.0 mg/kg/day p.o.	253 ± 7^*^†	42 ± 1^*^†
E2	0.1 mg/kg/day p.o.	231 ± 10^*^†	41 ± 3^*^†
EM	1.0 mg/kg/day p.o.	290 ± 10	51 ± 7^*^†
ABP	8 μg/kg/day s.c.	292 ± 15	130 ± 4^†

Ral, raloxifene; EM, EM652; ABP, alendronate.
↵* P < 0.05 vs. Ovx control
↵† P < 0.05 vs. Sham control