Significant gene ontology terms maintained at sham levels by drug treatment relative to Ovx Genes maintained at Sham level by all pharmaceutical agents and those uniquely maintained by estrogen and raloxifene were compared to Ovx-induced gene changes. All gene ontology terms listed were determined to be significant at a confidence level of p < 0.05 as described under Materials and Methods.
| Treatment | Biological Process | Molecular Function | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Metabolism | Response to Stimulus | Secretion | Transport | Cell Communication | Behavior | Catalytic Activity | Transporter Activity | Binding | Other | |
| Common (E2, Ral, EM, ABP) | cAMP biosynthesis | Growth hormone | Ion transport** (metal ion transport & K+ transport) | Cell-to-cell signaling, cell-to-cell adhesion, G protein signal coupled to a cyclic nucleotide 2nd messenger | Metallopeptidase | Neurotransmitter, ion channel activity | Enzyme regulatory activity | |||
| Ral | Coenzyme and prosthetic group metabolism* | Response to hypoxia, response to cell defense, response to bacteria | Oxidoreductase | Electron transporter activity | Cytoskeletal protein binding* | Chaperone (heat shock protein) | ||||
| E2 | Protein complex assembly** | Perception of pain, sensory perception of mechanical stimulus | Feeding behavior** | Antigen binding* | ||||||