Estimated IC50 values for the inhibition of l-[3H]glutamate uptake by human EAAT subtypes and l-[3H]glutamate uptake into rat cortical synaptosome fractions
Data are presented as mean ± S.E.M. from three independent experiments.
| EAAT2 | EAAT1 | EAAT3 | Synaptosomes | |
|---|---|---|---|---|
| nM | ||||
| WAY-213613 | 85 ± 5 | 5004 ± 1904 | 3787 ± 1927 | 35 ± 7 |
| WAY-213394 | 145 ± 22 | 1971 ± 162 | 6561 ± 2690 | 92 ± 13 |
| WAY-212922 | 157 ± 11 | 3426 ± 815 | 1837 ± 654 | 95 ± 8 |
| WAY-211686 | 190 ± 10 | 1681 ± 243 | 1453 ± 282 | 101 ± 20 |