TABLE 2

Kinetic parameters for α7–5HT3 Values are results of simultaneous fits of Schemes 1 and 2 to data from three different patches in the presence of 1 mM ACh. For Scheme 1, the log likelihood was 13,571, whereas that for Scheme 2 was 13,621. Data are expressed as seconds-1.

Scheme 1
   C21 2200 ± 116
   C12 6900 ± 440
   C11 40,500 ± 5000
   O11 11,000 ± 2500
   O12 7600 ± 940
   O21 424 ± 29
Scheme 2
   β1 10,400 ± 1700
   α1 7800 ± 1000
   β2 37,500 ± 3000
   α2 330 ± 24
   β12 1500 ± 120
   α12 6100 ± 760
   β22 540 ± 70
   α22 25 ± 3