TABLE 2

Interaction of various compounds with PMAT Values are given as means ± S.D. with n = 3.

Compound	K_m	K_i
μM
Dopamine	329 ± 8^a
l-DOPA		N.I.
Tyramine	283 ± 23
Norepinephrine	2606 ± 258^a
Epinephrine	15,323 ± 3947^a
Fluoxetine		22.7 ± 6.1^a
Pargyline		77.0 ± 28.0
Serotonin	114 ± 12^a
Tryptamine		62.9 ± 13.5
Histamine	10,471 ± 2550
Cimetidine		>500
MPP⁺	33 ± 7^a
NMN		>2000
Paraquat		N.I.
TEA	6593 ± 1702
Choline		>2000
Guanidine		>2000
Agmatine		N.I.
Creatinine		N.I.
Procainamide		>500
Desipramine		32.6 ± 2.7^a
Rhodamine123		1.02 ± 0.12
Decynium-22		0.10 ± 0.03^a
GBR12935		7.9 ± 1.0^a
Quinine		26.9 ± 4.6
Quinidine		25.3 ± 4.8
Verapamil		18.6 ± 3.1
Amantadine		<500
Clonidine		<500
Nicotine		<500
Corticosterone		450.5 ± 76.5^a
Thiamine		N.I.
PAH		N.I.^a
GABA		N.I.^a

N.I., no interaction at concentrations tested; PAH, p-aminohippurate; GBR12935, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)homopiperazine.
↵ a Values taken from Engel et al. (2004)