k1 (slow) | Half-Life Slow | k2 (fast) | Half-Life Fast | |
---|---|---|---|---|
× 10–2 min–1 | min | min–1 | min | |
Vehicle | 1.40 ± 0.08 | 49.4 (55.6–44.5) | 0.294 ± 0.037 | 2.35 (3.14–1.88) |
Org 27569 (100 nM) | 0.79 ± 0.03** | 87.8 (94.2–82.2) | 0.091 ± 0.006** | 7.59 (8.69–6.74) |
Org 27569 (1 μM) | 0.36 ± 0.03** | 194 (235–165) | 0.056 ± 0.005** | 12.43 (15.31–10.44) |
Org 27759 (1 μM) | 0.64 ± 0.03** | 108 (119–99) | 0.099 ± 0.008** | 7.03 (8.29–6.11) |
Org 27759 (10 μM) | 0.28 ± 0.03** | 249 (304–210) | 0.042 ± 0.004** | 16.36 (19.6–14.03) |
Org 29647 (1 μM) | 0.98 ± 0.04** | 71.0 (76.5–66.2) | 0.344 ± 0.026 | 2.01 (2.36–1.75) |
Org 29647 (10 μM) | 0.26 ± 0.004** | 264 (369–205) | 0.036 ± 0.005** | 19.53 (26.01–15.64) |
↵** P < 0.01, one-way analysis of variance followed by Dunnett's post test