Potency and maximal effect estimates for the inhibition of electrically evoked contractions of the mouse vas deferens by WIN 55,212 pEC50 is the negative logarithm of the agonist EC50 value and Emax is the maximal agonist effect, both determined using nonlinear regression analysis according to eq. 4 under Materials and Methods.
| pEC50 | Emax (95% CL) | |
|---|---|---|
| % | ||
| DMSO | 8.78 ± 0.083 | 82.7 (78.1–87.4) |
| Org 27569 (100 nM) | 8.64 ± 0.11 | 58.4 (54.6–62.1) |
| Org 27569 (1 μM) | 8.24 ± 0.12** | 45.4 (42.0–48.9) |
| DMSO | 8.80 ± 0.095 | 83.9 (78.5–89.3) |
| Org 27759 (100 nM) | 9.02 ± 0.122 | 65.2 (60.5–69.9) |
| Org 27759 (1 μM) | 7.79 ± 0.171** | 40.8 (35.7–45.9) |
| DMSO | 8.94 ± 0.131 | 90.0 (59.9–73.2) |
| Org 29647 (100 nM) | 8.79 ± 0.267 | 66.5 (59.9–73.2) |
| Org 29647 (1 μM) | 8.82 ± 0.251 | 57.2 (52.1–62.2) |
CL, confidence limits.
↵** P < 0.01, one-way analysis of variance followed by Dunnett's post test