The pA2 values of group B antagonists (AMG0610, capsazepine, and SB-366791) at the binding sites of group A antagonists (AMG6880, AMG7472, and BCTC) determined in pH 5-induced 45Ca2+ uptake into CHO cells stably expressing rat TRPV1 Slope values are shown in parentheses.
| AMG0610 | Capsazepine | SB-366791 | |
|---|---|---|---|
| AMG7472 | 7.30 ± 0.10 | 6.12 ± 0.07 | 6.58 ± 0.18 |
| (0.927 ± 0.017) | (0.976 ± 0.132) | (0.959 ± 0.070) | |
| BCTC | 6.78 ± 0.18 | 6.37 ± 0.10 | 6.33 ± 0.27 |
| (1.027 ± 0.041) | (1.087 ± 0.087) | (1.023 ± 0.168) | |
| AMG6880 | 6.71 ± 0.04 | 6.44 ± 0.22 | 6.32 ± 0.13 |
| (1.116 ± 0.090) | (0.979 ± 0.031) | (1.050 ± 0.258) |