Ligand | [3H]cAMP Accumulation | CRE-Luciferase Production | ||||
---|---|---|---|---|---|---|
Log EC50 | % Isoprenaline | n | Log EC50 | % Isoprenaline | n | |
Fenoterol | –7.56 ± 0.05 | 98.5 ± 1.0 | 4 | –7.56 ± 0.03 | 102.6 ± 1.6 | 14 |
Terbutaline | –5.53 ± 0.06 | 97.5 ± 1.4 | 6 | –5.68 ± 0.13 | 110.6 ± 3.0 | 4 |
Salbutamol | –5.76 ± 0.08 | 88.8 ± 3.0 | 4 | –5.76 ± 0.12 | 108.2 ± 2.0 | 4 |
Tulobuterol | –5.40 ± 0.05 | 76.6 ± 4.6 | 5 | –5.40 ± 0.12 | 107.7 ± 3.5 | 4 |
Cimaterol | –6.73 ± 0.08 | 86.2 ± 2.5 | 6 | –6.71 ± 0.04 | 106.3 ± 1.8 | 7 |
BRL 37344 | –7.38 ± 0.05 | 79.2 ± 3.4 | 4 | –7.52 ± 0.03 | 98.4 ± 1.7 | 13 |
Pronethalol | –5.34 ± 0.07 | 7.8 ± 3.7 | 9 | –4.82 ± 0.16 | 24.2 ± 11.0 | 3 |
ICI 215001 | –7.06 ± 0.06 | 60.3 ± 2.9 | 5 | –7.27 ± 0.03 | 89.2 ± 2.8 | 6 |
Clenbuterol | –5.90 ± 0.07 | 77.7 ± 2.8 | 4 | –5.91 ± 0.10 | 109.3 ± 2.2 | 4 |
Dobutamine | –6.27 ± 0.01 | 87.3 ± 1.6 | 5 | –6.29 ± 0.08 | 106.9 ± 3.4 | 4 |
CL 316243 | –6.03 ± 0.04 | 75.8 ± 4.5 | 6 | –6.17 ± 0.12 | 99.8 ± 3.8 | 4 |
Salmeterol | –6.23 ± 0.07 | 84.2 ± 2.5 | 5 | –6.15 ± 0.07 | 139.2 ± 1.9 | 4 |
Formoterol | –7.72 ± 0.08 | 99.6 ± 3.5 | 4 | –7.72 ± 0.10 | 113.0 ± 2.8 | 4 |
Noradrenaline | –7.14 ± 0.07 | 96.9 ± 2.2 | 6 | –7.29 ± 0.04 | 106.9 ± 2.1 | 8 |
Adrenaline | –6.55 ± 0.06 | 96.5 ± 1.8 | 5 | –6.67 ± 0.04 | 109.5 ± 2.1 | 7 |
Isoprenaline | –7.35 ± 0.05 | 100 | 5 | –7.48 ± 0.05 | 100 | 15 |
Labetolol | –5.32 ± 0.06 | 9.8 ± 0.5 | 10 | –4.97 ± 0.09 | 37.4 ± 2.1 | 5 |
Pindolol | –5.67 ± 0.06 | 39.3 ± 1.0 | 8 | –5.69 ± 0.05 | 90.1 ± 4.0 | 8 |
CGP 12177 | –6.57 ± 0.09 | 61.4 ± 1.5 | 6 | –6.93 ± 0.03 | 101.7 ± 1.4 | 15 |
SR 59230A | –7.21 ± 0.04 | 12.3 ± 0.8 | 9 | –6.49 ± 0.06 | 37.5 ± 5.7 | 10 |
Alprenolol | –5.69 ± 0.07 | 17.5 ± 1.3 | 6 | –5.56 ± 0.09 | 54.1 ± 5.5 | 10 |
Carvedilol | –7.19 ± 0.22 | 8.0 ± 0.5 | 9 | –6.10 ± 0.12 | 44.9 ± 6.5 | 6 |
Propanolol | –5.49 ± 0.10 | 7.5 ± 0.5 | 12 | –5.10 ± 0.10 | 23.1 ± 7.1 | 3 |
Timolol | –5.55 ± 0.14 | 5.7 ± 0.5 | 6 | –4.77 ± 0.07 | 20.4 ± 11.5 | 3 |