Log KD values for ICI 118551 (determined from [3H]cAMP accumulation and CRE-luciferase production experiments) and timolol and betaxolol (determined in CRE-luciferase experiments) in the presence of a range of agonists Values are mean ± S.E.M. of n determinations.
| Agonist | cAMP Accumulation | CRE-Luciferase Production | ||||||
|---|---|---|---|---|---|---|---|---|
| Log KD ICI 118551 | n | Log KD ICI 118551 | n | Log KD Betaxolol | n | Log KD Timolol | n | |
| Fenoterol | –6.24 ± 0.03 | 3 | –6.04 ± 0.02*** | 36 | –5.48 ± 0.08 | 5 | –6.86 ± 0.02 | 5 |
| Terbutaline | –6.24 ± 0.09 | 5 | –6.13 ± 0.05*** | 4 | –5.29 ± 0.04 | 3 | –6.93 ± 0.09 | 4 |
| Salbutamol | –6.30 ± 0.03 | 3 | –6.13 ± 0.06*** | 4 | –5.28 ± 0.10 | 3 | –6.88 ± 0.05 | 4 |
| Tulobuterol | –6.28 ± 0.06 | 4 | –6.13 ± 0.04*** | 4 | –5.25 ± 0.00 | 3 | –6.83 ± 0.05 | 4 |
| Cimaterol | –6.33 ± 0.07* | 5 | –6.09 ± 0.06*** | 5 | –5.51 ± 0.09 | 6 | –6.87 ± 0.04 | 6 |
| BRL 37344 | –6.13 ± 0.04 | 3 | –5.95 ± 0.02*** | 35 | –5.54 ± 0.08 | 5 | –6.87 ± 0.08 | 6 |
| Pronethalol | –6.05 ± 0.06 | 6 | N.D. | N.D. | N.D. | |||
| ICI 215001 | –6.04 ± 0.08 | 4 | –5.99 ± 0.05 | 4 | –5.41 ± 0.08 | 5 | –6.67 ± 0.04 | 5 |
| Clenbuterol | –6.23 ± 0.06 | 3 | –5.99 ± 0.04 | 4 | –5.17 ± 0.04 | 3 | –6.70 ± 0.04 | 4 |
| Dobutamine | –6.12 ± 0.06 | 4 | –5.97 ± 0.07 | 4 | –5.13 ± 0.00 | 3 | –6.60 ± 0.04 | 4 |
| CL 316243 | –6.08 ± 0.08 | 5 | –5.96 ± 0.11 | 4 | –5.17 ± 0.04 | 3 | –6.72 ± 0.05 | 4 |
| Salmeterol | –6.13 ± 0.06 | 4 | –5.94 ± 0.05 | 4 | –5.33 ± 0.04 | 3 | –6.59 ± 0.10 | 4 |
| Formoterol | –6.21 ± 0.04 | 3 | –5.92 ± 0.08 | 4 | –5.25 ± 0.00 | 3 | –6.77 ± 0.05 | 4 |
| Noradrenaline | –5.83 ± 0.08 | 5 | –5.89 ± 0.04 | 7 | –5.21 ± 0.05 | 7 | –6.57 ± 0.08 | 8 |
| Adrenaline | –5.99 ± 0.03 | 4 | –5.84 ± 0.08 | 6 | –5.24 ± 0.05 | 6 | –6.62 ± 0.08 | 7 |
| Isoprenaline | –5.87 ± 0.05 | 4 | –5.75 ± 0.03 | 39 | –5.17 ± 0.06 | 6 | –6.59 ± 0.06 | 5 |
| Labetolol | –5.53 ± 0.08* | 6 | –5.47 ± 0.04*** | 5 | –4.82 ± 0.08** | 5 | N.D. | |
| Pindolol | –5.29 ± 0.05*** | 7 | –5.24 ± 0.06*** | 8 | –4.57 ± 0.09*** | 7 | –5.80 ± 0.07*** | 8 |
| CGP 12177 | –4.87 ± 0.07*** | 5 | –5.17 ± 0.04*** | 33 | –4.78 ± 0.08** | 8 | –5.81 ± 0.07*** | 8 |
| SR 59230A | –5.13 ± 0.14*** | 6 | –5.17 ± 0.04*** | 6 | –4.24 ± 0.12*** | 5 | –5.60 ± 0.05*** | 4 |
| Alprenolol | –5.23 ± 0.06*** | 5 | –5.14 ± 0.03*** | 6 | –4.26 ± 0.09*** | 5 | –5.52 ± 0.09*** | 5 |
| Carvedilol | –4.79 ± 0.19*** | 5 | < –5 | 5 | < –4.5 | 4 | < –5 | 4 |