TABLE 3

Responses of ProbeSets that represent genes in the classic AH gene battery to AHR status or to AHR-TCDD interaction

Data are derived from array experiments as described under Materials and Methods. “AHR” represents the effect of having wild-type AHR (versus Ahr-/-), whereas “AHR-TCDD” represents the effect of TCDD treatment in mice with wild-type AHR (Ahr+/+ mice). As in Table 2, “M” represents the magnitude in log2-space for each contrast. There are multiple entries in the table for some genes because the array contains multiple ProbeSets for these genes.

ProbeSet LocusLink Gene M
AHR AHR-TCDD
1422217_a_at 13076 Cyp1a1 -0.5 7.7*
1450715_at 13077 Cyp1a2 2.0* 1.4*
1416612_at 13078 Cyp1b1 0.1 7.9*
1416613_at 13078 Cyp1b1 0.1 6.0*
1448330_at 14862 GST, μ1 -0.2 0.6*
1425627_x_at 14862 GST, μ1 -0.3† 0.5*
1416416_x_at 14862 GST, μ1 -0.2† 0.4*
1423627_at 18104 Nqo1 -0.8 4.5*
1452161_at 99929 Tiparp 0.0 5.5*
1452160_at 99929 Tiparp 0.0 5.3*
1426721_s_at 99929 Tiparp 0.1 5.3*
1426261_s_at 94284 Ugt1a6 0.1* 0.6*
1424783_a_at 84284 Ugt1a6 0.0 0.5*

  • P450, cytochrome P450.

  • ↵* Effects showing statistically significant up-regulation (p < 10-3 in the nested F test).

  • ↵† Effects showing statistically significant down-regulation.