Ontological analysis of the AHR effect on transcript expression
Ontological analysis used the GOMiner software package (Zeeberg et al., 2003), which performs a two-tailed Fisher's exact test to determine over-representation of GO categories in the gene list relative to the array as a whole. The GO term and name are given, along with the total number of genes in the category and the numbers of over- and underexpressed genes that have this annotation. p values, shown in parentheses, are calculated for enrichment of the term as a whole and for enrichment of the term among over- and underexpressed genes alone. GO categories shown were selected from those showing statistical significance (P < 0.001) in the AHR effect.
| GO | Total | Under | Over | Name |
|---|---|---|---|---|
| GO:0006725 | 68 (<10-4) | 7 (<10-4) | 2 (0.1505) | Aromatic compound metabolism |
| GO:0006118 | 239 (<10-4) | 13 (<10-4) | 6 (0.034) | Electron transport |
| GO:0016705 | 63 (<10-4) | 9 (<10-4) | 2 (0.1332) | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| GO:0016491 | 483 (<10-4) | 25 (<10-4) | 16 (<10-4) | Oxidoreductase activity |
| GO:0004497 | 80 (<10-4) | 7 (0.0001) | 4 (0.0087) | Monooxygenase activity |
| GO:0005792 | 85 (<10-4) | 7 (0.0001) | 5 (0.0017) | Microsome |
| GO:0006082 | 245 (0.0001) | 14 (<10-4) | 3 (0.4524) | Organic acid metabolism |
| GO:0006519 | 153 (0.0002) | 11 (<10-4) | 1 (0.7912) | Amino acid and derivative metabolism |
| GO:0009308 | 174 (0.0002) | 12 (<10-4) | 1 (0.832) | Amine metabolism |
| GO:0009310 | 39 (0.0003) | 5 (0.0001) | 1 (0.3277) | Amine catabolism |
| GO:0008483 | 27 (0.0003) | 5 (<10-4) | 0 (1) | Transaminase activity |
| GO:0006520 | 116 (0.0004) | 10 (<10-4) | 0 (1) | Amino acid metabolism |
| GO:0016769 | 28 (0.0004) | 5 (<10-4) | 0 (1) | Transferase activity, transferring nitrogenous groups |
| GO:0009074 | 8 (0.0006) | 3 (0.0001) | 0 (1) | Aromatic amino acid family catabolism |
| GO:0009063 | 30 (0.0006) | 5 (<10-4) | 0 (1) | Amino acid catabolism |
| GO:0007162 | 9 (0.0009) | 0 (1) | 3 (0.0001) | Negative regulation of cell adhesion |