Ontological analysis of the AHR-TCDD interaction on transcript expression
Ontological analysis used the GOMiner software package (Zeeberg et al., 2003), which performs a two-tailed Fisher's exact test to determine over-representation of GO categories in the gene list relative to the array as a whole. The GO term and name are given, along with the total number of genes in the category and the numbers of over- and underexpressed genes that have this annotation. p values, shown in parentheses, are calculated for enrichment of the term as a whole and for enrichment of the term among over- and underexpressed genes alone. GO categories shown were selected from those showing statistical significance (P < 0.001) in the AHR effect. GO categories shown were selected from those showing statistical significance (p < 0.001) in the AHR-TCDD effect.
| GO | Total | Under | Over | Name |
|---|---|---|---|---|
| GO:006725 | 68 (<10-4) | 3 (0.0095) | 7 (0.0002) | Aromatic compound metabolism |
| GO:006412 | 349 (<10-4) | 0 (1) | 22 (<10-4) | Protein biosynthesis |
| GO:006118 | 239 (<10-4) | 3 (0.1994) | 19 (<10-4) | Electron transport |
| GO:0016616 | 67 (<10-4) | 2 (0.0692) | 11 (<10-4) | Oxidoreductase activity, acting on the CH-OH group of donors, NAD, or NADP as acceptor |
| GO:009310 | 39 (<10-4) | 4 (0.0001) | 3 (0.0315) | Amine catabolism |
| GO:004497 | 80 (<10-4) | 2 (0.0938) | 10 (<10-4) | Monooxygenase activity |
| GO:0030529 | 226 (<10-4) | 0 (1) | 21 (<10-4) | Ribonucleoprotein complex |
| GO:009058 | 687 (<10-4) | 7 (0.1519) | 31 (<10-4) | Biosynthesis |
| GO:0019843 | 7 (<10-4) | 0 (1) | 4 (<10-4) | rRNA binding |
| GO:005840 | 137 (<10-4) | 0 (1) | 19 (<10-4) | Ribosome |
| GO:005792 | 85 (<10-4) | 2 (0.1039) | 12 (<10-4) | Microsome |
| GO:008152 | 4159 (<10-4) | 29 (0.3312) | 109 (<10-4) | Metabolism |
| GO:004499 | 4 (0.0001) | 0 (1) | 3 (<10-4) | Dimethylaniline monooxygenase (N-oxide-forming) activity |
| GO:0042254 | 62 (0.0001) | 0 (1) | 8 (<10-4) | Ribosome biogenesis and assembly |
| GO:007046 | 59 (0.0001) | 0 (1) | 8 (<10-4) | Ribosome biogenesis |
| GO:006631 | 89 (0.0003) | 3 (0.0196) | 6 (0.0049) | Fatty acid metabolism |
| GO:006519 | 153 (0.0003) | 8 (<10-4) | 4 (0.288) | Amino acid and derivative metabolism |
| GO:0015036 | 15 (0.0004) | 0 (1) | 4 (0.0001) | Disulfide oxidoreductase activity |
| GO:0016789 | 76 (0.0005) | 0 (1) | 8 (0.0001) | Carboxylic ester hydrolase activity |
| GO:004364 | 16 (0.0005) | 0 (1) | 4 (0.0001) | Glutathione transferase activity |
| GO:009074 | 8 (0.0007) | 3 (<10-4) | 0 (1) | Aromatic amino acid family catabolism |