Transcription factor binding sites common to all conditions
p values for transcription factor binding sites that were found to be over-represented in all four of the effects studied. Here, AHR(↓) refers to genes with negative AHR effects, whereas AHR-TCDD(↑) refers to genes with positive interactions. The ID number refers to the JASPAR identifier of the matrix used for testing the specific TFBSs. The p values given here were obtained by dinucleotide randomization studies (1000 iterations). Of the 15 TFBSs here, only five are under-represented (MA0054, MA0103, MA0036, and MA0024), whereas 10 are over-represented. Many of these TFBSs are likely to be liver-specific rather than AHR-specific.
| ID | Transcription Factor Name | AHR (↓) | AHR (↑) | AHR-TCDD (↓) | AHR-TCDD (↑) |
|---|---|---|---|---|---|
| MA0041 | HFH-2 FORKHEAD | <10-3 | <10-3 | <10-3 | <10-3 |
| MA0042 | HFH-3 FORKHEAD | <10-3 | <10-3 | <10-3 | <10-3 |
| MA0055 | Myf bHLH | <10-3 | <10-3 | <10-3 | <10-3 |
| MA0047 | HNF-3β FORKHEAD | <10-3 | <10-3 | <10-3 | <10-3 |
| MA0015 | CF2-II ZN-FINGER, C2H2 | <10-3 | <10-3 | <10-3 | <10-3 |
| MA0094 | Ubx HOMEO | 0.001 | <10-3 | <10-3 | <10-3 |
| MA0017 | COUP-TF NUCLEAR RECEPTOR | 0.014 | 0.001 | 0.003 | <10-3 |
| MA0088 | Staf ZN-FINGER, C2H2 | <10-3 | 0.010 | <10-3 | <10-3 |
| MA0086 | Snail ZN-FINGER, C2H2 | 0.035 | <10-3 | 0.116 | 0.003 |
| MA0057 | MZF_5-13 ZN-FINGER, C2H2 | <10-3 | 0.014 | 0.183 | 0.164 |
| MA0054 | MYB.ph3 TRP-CLUSTER | 0.997 | 0.955 | 0.946 | 0.898 |
| Custom | AHRE-II | 0.957 | 0.897 | 0.892 | 0.999 |
| MA0103 | δEF1 ZN-FINGER, C2H2 | 0.969 | 0.923 | 0.981 | 0.999 |
| MA0036 | GATA-2 ZN-FINGER, GATA | 1 | 1 | 1 | 1 |
| MA0024 | E2F unknown | 1 | 1 | 1 | 1 |