Receptors | Nicotine | Acetylcholine | DMPP | Cytisine | MCC | DHβE | Mecamylamine | |
---|---|---|---|---|---|---|---|---|
Control | nM | |||||||
Inhibition IC50 | α4β2 | 6.1 ± 3.6 | 88 ± 24 | 770 ± 220 | ||||
Activation EC50 | (α4)2(β2)3 | 116 ± 15 | 230 ± 40 | 1110 ± 550 | 57 ± 20 | 3200 ± 1000 | >1,000,000 | |
(α4)3(β2)2 | 2700 ± 200 | 57,000 ± 20,000 | ||||||
Nicotine-treated | ||||||||
Activation EC50 | (α4)2(β2)3 | 345 ± 40 | 320 ± 10 | 1320 ± 190 | >1,000,000 | |||
(α4)3(β2)2 | 71,000 ± 37,000 |