Compound and Channel | Inhibition (KD) | n | |
---|---|---|---|
60 mV | -140 mV | ||
μM | |||
FFA | |||
CLC-Ka | 121 ± 37 | 57 ± 8 | 20 |
CLC-Ka N68D | >5000 | >1000 | 5 |
TFA | |||
CLC-Ka | 148 ± 22 | 195 ± 47 | 5 |
CLC-Ka N68D | >1000 | >1000 | 4 |
MFA | |||
CLC-Ka | 103 ± 24 | 107 ± 11 | 4 |
CLC-Ka N68D | >1000 | >5000 | 4 |
MCFA | |||
CLC-Ka | 43 ± 6 | 39 ± 8 | 5 |
CLC-Ka N68D | 632 ± 101 | 172 ± 39 | 4 |
DPC | |||
CLC-Ka | 502 ± 135 | >5000 | 3 |
CLC-Ka N68D | >5000 | >3000 | 3 |
3-Phenyl-CPP | |||
CLC-Ka | 79 ± 5 | 184 ± 18 | 23 |
CLC-Ka N68D | 424 ± 38 | 934 ± 87 | 10 |