TABLE 4

Antagonists of wild-type α7 and their effect on the T6′S mutant expressed in X. laevis oocytes Percentage reduction in peak amplitude when coapplied with 30 μM acetylcholine relative to a 30 μM acetylcholine control application. Each mean and S.E.M. represent data obtained from at least four oocytes.

Drug	Inhibition
Drug	Wild-type α7	T6′S
	%
Bicuculline, 10 μM	∼63^a	88 ± 3
5-HT, 20 μM	∼25^b	100
Tubocurarine, 1 μM	∼28^c	97 ± 2
Hexamethonium, 100 μM	100^d	60 ± 12

↵ a Demuro et al., 2001
↵ b Palma, 1996
↵ c Briggs et al., 1999
↵ d Bertrand et al., 1992a