Numbering of residues mutated in this study
Numbering is provided for both receptors at positions that were mutated in either receptor. For TM residues, the index number is that of Ballesteros and Weinstein (1995), and for EL2 residues, the index denotes the position of the residue relative to the conserved Cys in that loop.
| D2 Residue | D1 Residue | Index Number |
|---|---|---|
| Phe110a | Trp99 | 3.28 |
| Ile183 | Asp187 | +1 |
| Ile184 | Ser188 | +2 |
| Ala185 | Ser189 | +3 |
| Asn186 | Leu190 | +4 |
| Phe189 | Tyr194 | 5.38 |
| Val190 | Ala195 | 5.39 |
| His394 | Asn292 | 6.55 |
| Leu408 | Thr312 | 7.34 |
| Tyr409a | Phe313 | 7.35 |
| Ser410 | Asp314 | 7.36 |
| Thr413a | Val317 | 7.39 |
| Tyr417a | Trp321 | 7.43 |
↵ a Residues predicted to be in the ancillary binding pocket according to our D2 receptor homology model (Neve et al., 2003).