Bmax and pKI or pIC50 values determined from 125I-BE 2254 saturation and competition radioligand binding assays in HEK293 cells expressing α1D-ARs
| Subtypes Expressed | Bmax | BMY 7378 | %high | F18A | %high | ||
|---|---|---|---|---|---|---|---|
| pKI high | pKlow | pIC50 high | pIC50 low | ||||
| fmol/mg | |||||||
| α1D + pREP4 | 1204 ± 46 | -8.7 ± 0.1 | 100 | -7.4 ± 0.03 | 100 | ||
| α1D + HAα1B | 1070 ± 117 | -6.1 ± 0.01 | 0 | -9.0 ± 0.04 | -7.0 ± 0.07 | 66 | |
| α1D + HAα1A | 1845 ± 19 | -9.3 ± 0.2 | -5.9 ± 0.04 | 14 | -7.6 ± 0.26 | -5.9 ± 0.09 | 27 |