TABLE 1

Human LGIC subunit genes/gene products

Various human genes/gene products for each receptor cloned to date and listed in the current version of the ligand-gated ion channel database [http://www.ebi.ac.uk/compneur-srv/LGICdb/LGICdb.php (Le Novere and Changeux, 2001)]. Please note that not all of the gene products have been unequivocally demonstrated to be incorporated into LGICs in vivo.

Serotonin type 3 receptor HTR3A, HTR3B, HTR3C, HTR3D, HTR3E
GABAAR α1, α2, α3, α4, α5, α6, β1, β2, β3, γ1, γ2, γ3, δ, ϵ, π, ρ1, ρ2, ρ3, θ
Glycine receptor α1, α2, α4, β
Muscle AChR α1,b1, γ, δ, ϵ
Neuronal AChR α2, α3, α4, α5, α6, α7, α9, α10, β2, β3, β4