CcoTx1 | CcoTx2 | CcoTx3 | PaurTx3 | |
---|---|---|---|---|
IC50 values (maximal toxin addition is 2 μM) | ||||
Nav1.1/β1 | 523 ± 79 nM (0.9) | 407 ± 36 nM (1.4) | N.A. | 610 ± 63 nM (0.9) |
Nav1.2/β1 | 3 ± 1 nM (1.3) | 8 ± 1 nM (1.1) | N.A. | 0.6 ± 0.1 nM (1.0) |
Nav1.3/β1 | N.A. | 88 ± 25 nM (1.8) | N.A. | 42 ± 4 nM (1.1) |
Nav1.4/β1 | 888 ± 80 nM (1.0) | 400 ± 54 nM (1.3) | N.A. | 288 ± 58 nM (1.5) |
Nav1.5/β1 | 323 ± 56 nM (1.5) | 1634 ± 133 nM (1.0) | 447 ± 32 nM (1.7) | 72 ± 10 nM (1.5) |
Nav1.8/β1 | 55% block | 40% block | 45% block | 65% block |
ΔV½ values (representative sodium currents <1.5 μA) | ||||
Nav1.2/β1 | +1.7 mV | +5.3 mV | — | +1.9 mV |
Nav1.2/β1 | +14.3 mV | +17.0 mV | — | +10.7 mV |
Nav1.3/β1 | +7.5 mV | +5.1 mV | — | +10.2 mV |
Nav1.4/β1 | +19.8 mV | +20.5 mV | +10.4 mV | +5.9 mV |
Nav1.5/β1 | +6.1 mV | +9.1 mV | +1.5 mV | +12.9 mV |
Nav1.8/β1 | — | — | — | — |
NA, no activity; —,no significant shift of V½.