Effects of long-term nicotine treatment and its withdrawal on brain [3H]epibatidine ([3H]epi) and 125I-αBgt binding sites
| [3H]Epibatidine Binding Sites | [125I]αBgt Binding Sites | |||||
|---|---|---|---|---|---|---|
| Treatment | MiniPump 14 days | Withdrawal | MiniPump 14 days | Withdrawal | ||
| 3 days | 7 days | 3 days | 7 days | |||
| fmol/mg | ||||||
| Saline | 99.7 ± 8.2 | 90.4 ± 9.0 | 81.0 ± 10.9 | 117.1 ± 5.0 | 109.2 ± 4.2 | 102.4 ± 6.1 |
| Nicotine | 137.1 ± 15.7* | 128.4 ± 5.6* | 119.0 ± 9.1* | 114.6 ± 7.3 | 112.9 ± 6.4 | 105.2 ± 11.7 |
| n | 16 | 16 | 16 | 16 | 16 | 16 |
↵* Statistically different from respective control, p < 0.05, one-way ANOVA.