Modulation of the GABA-induced chloride currents by 1 μM concentration of the indicated compounds for receptors composed of α1β2γ1 subunits (second column) and α1β2 subunits (third column) Each value represents the mean ± S.E. of at least four oocytes from at least two oocyte batches.
| Compound | IGABA (EC5-10) Potentiation | |
|---|---|---|
| α1β2γ1 | α1β2 | |
| % | ||
| Triazolam | 82 ± 10* | -21 ± 4* |
| Clotiazepam | 53 ± 8* | -14 ± 2* |
| Midazolam | 43 ± 4* | -20 ± 5* |
| CGS 20625 | 42 ± 4* | 20 ± 5* |
| CGS 9896 | 24 ± 3* | 16 ± 7 |
| Diazepam | 20 ± 3* | 2 ± 2 |
| Zolpidem | 13 ± 3* | -5 ± 3 |
| Bretazenil | 10 ± 1* | -1 ± 5 |
| DMCM | 8 ± 4 | 4 ± 2 |
| Cl 218,872 | 6 ± 5 | -10 ± 1* |
| Clobazam | 5 ± 2 | 7 ± 3 |
| Flumazenil | 4 ± 3 | 13 ± 5 |
| Ru 33203 | 2 ± 2 | -5 ± 5 |
| PK 9084 | -3 ± 3 | -6 ± 4 |
| Flurazepam | -5 ± 3 | 26 ± 4* |
| l-655708 | -7 ± 2 | -8 ± 5 |
| Ru 31719 | -7 ± 3 | -10 ± 5 |
| Ru 33356 | -7 ± 3 | -2 ± 3 |
| Ru 32698 | -8 ± 2 | -5 ± 2 |
| Flunitrazepam | -11 ± 2* | -9 ± 5 |
| PK 8165 | -16 ± 2* | -14 ± 2* |
↵* Difference from zero was calculated by ANOVA.