TABLE 5
Properties of the nonlinear model to reproduce GI50 patterns for some selected drugs The table gives the correlation between the fitted predictions of cellular GI50 values to the true GI50 values and to the individual drug GI50 values in the second and third column. Compounds (5I-203 and aminoflavone) that show a significant correlation with the 5F-203 toxicity profile can be fitted better using the seven selected genes than those with low or insignificant correlations. The last entries show the correlation value of the true GI50 values to the nonlinear model predictions when using only the seven genes that were originally deselected as unsuitable from the gene set shown in Table 3.
| PCC | |||
|---|---|---|---|
| Drug | Fitted  with GI50 Profile r (r2) | GI50 Profile with 5F-203 | Fitted  with GI50 Profile Using Deselected Genes r (r2) |
| 5F-203 | 0.90 (0.80) | 1.00 | 0.65 (0.42) |
| 5I-203 | 0.90 (0.80) | 0.63 | |
| Paclitaxel | 0.73 (0.53) | 0.04 | 0.44 (0.19) |
| 5-FU | 0.65 (0.42) | 0.21 | 0.29 (0.08) |
| Bleomycin | 0.73 (0.53) | –0.04 | 0.66 (0.44) |
| Aminoflavone | 0.77 (0.59) | 0.38 | 0.68 (0.46) |