TABLE 2

IC50 values of TAK-242 for inhibition of IL-1β, TNF-α, and IL-6 production by human PBMCs The 95% confidence intervals of the IC50 values have not been shown because the variance of the duplicate data in low concentrations of TAK-242 was too large for precise estimation.

Donor IC50
IL-1β TNF-α IL-6
nM
A 10 6.0 28
B 21 11 37
C 26 20 11
D 14 5.3 58
Mean ± S.E. 18 ± 3.5 11 ± 3.3 33 ± 9.8