TABLE 3

Mutation frequency

Total number of mutations/1000 nt is shown. The x-fold difference with the untreated virus control is presented in parentheses.

Mutation Virus Control Ribavirin EICAR MPA
A to G 0.465 0.291(0.6) 0.291(0.6) 0.279(0.6)
U to C 0.465 0.226(0.5) 0.776(1.7) 0.248(0.5)
C to U 0.093 0.226(2.4) 0.032(0.3) 0.217(2.3)
G to A 0.217 0.194(0.9) 0.129(0.6) 0.279(1.3)