TABLE 1

Aligned sequences of K⁺ channels

Residues that contribute to d-tubocurarine binding in the models of BK and Kv1.3 are underlined. Bold type indicates residues in which mutation affects binding of ligands in Kv1.3 (Hanner et al., 2001), HERG (Mitcheson et al., 2000), Kv1.5 (Decher et al., 2004), and Kv7.1 (Seebohm et al., 2003).

		P-loop			Inner helix
	33	41	51^a	1	11	21	31^a
KcsA	LITYPRAL	WWSVETATTV	GYGD	LWGRLVAVVV	MVAGITSFGL	VTAALATWFV	G
MthK	GESWTVSL	YWTFVTIATV	GYGD	PLGMYFTVTL	IVLGIGTFAV	AVERLLEFLI	N
KvAP	IKSVFDAL	WWAVVTATTV	GYGD	PIGKVIGIAV	MLTGISALTL	LIGTVSNMFQ	K
BK	ALTYWECV	YLLMVTMSTV	GYGD	TLGRLFMVFF	ILGGLAMFAS	YVPEIIELIG	N
SK3				YCGKGVCLLT	GIMGAGCTAL	VVAVVARKLE	L
Kv1.3	FNSIPDAF	WWAVVTMTTV	GYGD	IGGKIVGSLC	AIAGVLTIAL	PVPVIVSNFN	Y
Kv1.5	FSSIPDAF	WWAVVTMTTV	GYGD	VGGKIVGSLC	AIAGVLTIAL	PVPVIVSNFN	Y
HERG	KDKYVTAL	YFTFSSLTSV	GFGN	NSEKIFSICV	MLIGSLMYAS	IFGNVSAIIQ	R
Kv7.1	FGSYADAL	WWGVVTVTTI	GYGD	WVGKTIASCF	SVFAISFFAL	PAGILGSGFA	L

HERG, human ether-a-go-go-related gene.
↵ a Relative numbers of residues (Zhorov and Tikhonov, 2004).