Compounds | Mutations in VZV TK | ||||||
---|---|---|---|---|---|---|---|
Wild Type | E59S | R84V | H97A | H97Y | Y21H | Y21E | |
μM | |||||||
BVDU | 1.5 ± 0.1 | 5.9 ± 0.6 | 7.0 ± 0.1 | 4.7 ± 0.3 | 10 ± 5 | 14 ± 0 | 2.2 ± 0.9 |
IVDU | 1.2 ± 0.1 | 5.6 ± 0.0 | 5.0 ± 0.1 | 5.1 ± 0.1 | 7.3 ± 0.1 | 8.8 ± 3.1 | 1.8 ± 0.2 |
BvaraU | 1.4 ± 0.2 | 5.2 ± 0.3 | 6.6 ± 1.9 | 3.0 ± 1.3 | 19 ± 8 | 22 ± 1 | 1.7 ± 0.2 |
araT | 20 ± 1 | 39 ± 1 | 116 ± 55 | 80 ± 10 | 11 ± 18 | 173 ± 38 | 34 ± 2 |
FIAU | 17 ± 1 | 35 ± 1 | 20 ± 11 | 34 ± 8 | 31 ± 3 | 34 ± 0 | 2.3 ± 0.1 |
Acyclovir | >500 | >500 | >500 | >500 | >500 | >500 | >500 |
Ganciclovir | >500 | >500 | >500 | >500 | >500 | >500 | >500 |
Penciclovir | >500 | >500 | >500 | >500 | >500 | >500 | >500 |
Cf1743 | 5.5 ± 3.3 | 298 ± 81 | 11 ± 7 | 27 ± 4 | 4.5 ± 0.5 | 223 ± 222 | 13 ± 5 |
Cf1368 | 33 ± 1 | 161 ± 131 | 19 ± 7 | 28 ± 4 | 38 ± 1 | >500 | 7.5 ± 5.0 |