Effect of 9-nitro-nos on cell cycle progression of drug-resistant cell lines and their normal counterparts Cells were treated with 9-nitro-nos for the indicated times before being stained with propidium iodide for cell cycle analysis.
| Cell Cycle Parameters | CEM | CEM/VLB100 | CEM/VM-1-5 | 1A9 | 1A9/PTX22 | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 h | 24 h | 48 h | 72 h | 0 h | 24 h | 48 h | 72 h | 0 h | 24 h | 48 h | 72 h | 0 h | 24 h | 48 h | 72 h | 0 h | 24 h | 48 h | 72 h | |
| % | ||||||||||||||||||||
| G0/G1 | 45.5 | 24.8 | 19.7 | 13.9 | 46.9 | 25.5 | 23.7 | 8.7 | 36.0 | 25.4 | 13.7 | 10.5 | 50.0 | 30.6 | 28.6 | 16.7 | 57.0 | 27.3 | 5.9 | 14.1 |
| S | 25.0 | 10.0 | 8.1 | 8.9 | 17.6 | 17.7 | 9.3 | 4.5 | 19.4 | 13.0 | 11.0 | 8.7 | 21.8 | 14.3 | 10.6 | 9.6 | 8.8 | 4.7 | 3.4 | 5.7 |
| G2/M | 20.9 | 34.2 | 40.0 | 16.9 | 25.7 | 36.0 | 30.2 | 12.5 | 30.7 | 41.0 | 15.0 | 12.2 | 21.2 | 34.2 | 17.2 | 9.0 | 20.4 | 31.4 | 44.3 | 13.7 |
| Sub-G1 | 0.25 | 6.5 | 23.8 | 44.3 | 3.6 | 14.8 | 30.7 | 56.1 | 3.4 | 18.8 | 58.0 | 63.0 | 0.7 | 12.0 | 38.0 | 56.3 | 3.5 | 30.0 | 44.6 | 59.0 |