Potencies (pEC0.5,diss) of W84 to retard [3H]NMS dissociation from the indicated wild-type and mutant receptors
ΔpEC0.5,diss indicate the difference between the pEC0.5,diss values for the mutant and for the respective wild-type receptor. Values are means ± S.E. of three to five separate experiments.
| pEC0.5,diss | ΔpEC0.5,diss (Mutant-Wild Type) | |
|---|---|---|
| M2 wild type | 7.40 ± 0.03 | |
| M2422W→A | 5.89 ± 0.04 | -1.51 |
| M2423T→A | 7.44 ± 0.04 | +0.04 |
| M2423T→H | 6.61 ± 0.05a | -0.79 |
| M2422W→A + 423T→H | 5.14 ± 0.07 | -2.26 |
| M5 wild type | 5.41 ± 0.04 | |
| M5477W→A | 3.24 ± 0.54 | -2.17 |
| M5478H→A | 6.11 ± 0.02 | +0.70 |
| M5478H→T | 6.18 ± 0.10a | +0.77 |
| M5477W→A + 478H→T | 4.63 ± 0.08 | -0.78 |