Peptides | cAMP Stimulation EC50 |
---|---|
Secretin | 139 ± 20 pM |
SecR (24-53) | 24 ± 5 μM |
LWDNM, linear | 32 ± 3.8 μM |
WDN, linear | 55 ± 16 μM |
WDN, cyclic | 5.9 ± 1.2 μM |
Myr-WDN, cyclic | 1.1 ± 0.3 μM |
WDN-Bpa | 7.9 ± 2.0 μMa |
Bpa-WDN | 8.8 ± 2.1 μMa |
VPAC1(51-71) | 4.1 ± 1.6 μM |
↵ a EC40 values were used for these compounds because limited solubilities precluded the curves reaching 50% of maximal levels of cAMP with achievable concentrations.