Compound | EC50 (Ki) | ||||
---|---|---|---|---|---|
hENT1 | hENT2 | hCNT1 | hCNT2 | hCNT3 | |
μM | |||||
Cytidine | 171 (167) | 650 (647) | 17 (16.4) | 1445 (1397) | 5 (4) |
2′-Deoxycytidine | 288 (282) | 1035 (1030) | 9 (8.6) | 1714 (1657) | 7 (6.3) |
Gemcitabine | 362 (354) | 784 (780) | 13.4 (13) | 1365 (1320) | 25 (22.3) |
AraC | 788 (771) | 760 (756) | >2000a | >10,000a | >10,000a |
TaraC | >1000a | >3000a | 459 (451) | >3000a | >2000a |
3′-Deoxycytidine | >2000a | >10,000a | >2000a | >20,000a | >10,000a |
2′,3′-Dideoxycytidine | >10,000a | >20,000a | >5000a | >20,000a | >10,000a |
↵ a Ki values were not calculated due to high EC50 values.