TABLE 1

Single nucleotide polymorphisms identified in 1.5-kb region of the MDR1 promoter

Bold values represent statistical difference (at P value indicated) between the population indicated in the row and the population indicated in the column.

SNP no. SNP ID Population n HWE P Value Allele Frequency Pairwise Differences Fisher's Exact P Value
A C T G CH ML IN EA AA
%
1 I-1/-274 (G/A) CH 89 1.00 0.0 100.0 1.00 1.00 1.00 0.50
ML 86 1.00 0.0 100.0 1.00 1.00 0.50
IN 88 1.00 0.0 100.0 1.00 0.50
EA 95 1.00 0.0 100.0 0.23
AA 89 0.91 1.1 98.9
2 I-1/-223 (C/T) CH 89 1.00 100.0 0.0 1.00 1.00 1.00 1.00
ML 86 1.00 100.0 0.0 1.00 1.00 1.00
IN 88 1.00 100.0 0.0 1.00 1.00
EA 95 0.96 99.5 0.5 1.00
AA 89 1.00 100.0 0.0
3 I-1/-146 (T/C) CH 89 1.00 0.0 100.0 1.00 1.00 1.00 1.00
ML 86 1.00 0.0 100.0 1.00 1.00 1.00
IN 88 1.00 0.0 100.0 1.00 1.00
EA 95 1.00 0.0 100.0 0.48
AA 89 0.96 0.6 99.4
4 I-1/-60 (A/T) CH 89 1.00 100.0 0.0 1.00 1.00 1.00 0.01
ML 86 1.00 100.0 0.0 1.00 1.00 0.01
IN 88 1.00 100.0 0.0 1.00 0.01
EA 95 1.00 100.0 0.0 5.82 × 10-3
AA 89 0.02 96.1 3.9
5 I-1/-41 (A/G) CH 89 0.20 89.9 10.1 0.11 4.87 × 10-6 1.64 × 10-5 5.09 × 10-5
ML 86 0.61 94.8 5.2 1.58 × 10-3 7.86 × 10-3 9.56 × 10-3
IN 88 1.00 100.0 0.0 1.00 1.00
EA 95 0.96 99.5 0.5 1.00
AA 89 0.96 99.4 0.6
6 E1/-145 (C/G) CH 89 0.96 99.4 0.6 1.00 1.00 0.48 1.00
ML 86 1.00 100.0 0.0 1.00 1.00 1.00
IN 88 1.00 100.0 0.0 1.00 1.00
EA 95 1.00 100.0 0.0 1.00
AA 89 1.00 100.0 0.0
7 e1/-129 (T/C) CH 89 0.66 4.5 95.5 0.81 0.04 1.00 0.49
ML 86 0.61 5.2 94.8 9.9 × 10-3 1.00 0.65
IN 88 0.96 0.6 99.4 0.02 2.91 × 10-3
EA 95 0.62 4.7 95.3 0.50
AA 89 0.32 6.7 93.3
8 E1/-43 (A/G) CH 89 1.00 100.0 0.0 1.00 1.00 1.00 0.12
ML 86 1.00 100.0 0.0 1.00 1.00 0.12
IN 88 1.00 100.0 0.0 1.00 0.12
EA 95 1.00 100.0 0.0 0.05
AA 89 0.83 97.8 2.2