Effects of BmK M1 on fast activation and inactivation parameters for Nav1.7 and Nav1.3
| Activation | Inactivation | |||||
|---|---|---|---|---|---|---|
| V½ | Slope | n | V½ | Slope | n | |
| mV | mV | |||||
| Na1.7 | ||||||
| Control | −17.9 ± 0.7 | 4.4 ± 0.2 | 4 | −46.4 ± 0.8* | 8.9 ± 0.5 | 4 |
| BmK M1 50 nM | −18.5 ± 0.3 | 3.6 ± 0.1 | 4 | −44.1 ± 0.7* | 8.3 ± 0.3 | 4 |
| Nav1.3 | ||||||
| Control | −15.7 ± 0.3 | 3.7 ± 0.2 | 4 | −31.2 ± 0.2 | 7.4 ± 0.2 | 4 |
| BmK M1 50 nM | −14.4 ± 0.3 | 4.4 ± 0.3 | 4 | −29.4 ± 0.1 | 7.8 ± 0.1 | 4 |
↵* P < 0.05