Compound | TPase Enzyme Assay IC50 | CAM Assaya (250 nmol) | |
---|---|---|---|
μM | % of inhibition | ||
KIN59 | 5′-O-Trityl-inosine | 30 ± 8.7a | −89 ± 10 |
TP136 | 5′-O-(4-Chlorotrityl)-inosine | 4.5 ± 1.6 | −89 ± 6 |
TP140 | 5′-O-Trityl-1-methylinosine | 49 ± 2.5 | +3 ± 18 |
TP124 | 1-(5′-O-Trityl-β-d-ribofuranosyl)thymine | 12 ± 1.6 | −28 ± 24 |
KIN6 | 5′-O-Trityl-thymidine | 8.6 ± 0.8 | −27 ± 16 |
TP134 | 5′-O-Trityl-uridine | 18 ± 0.5 | −76 ± 7 |
TP137 | 5′-O-Trityl-2′-deoxy-5-methylcytidine | 55 ± 9.2 | −92 ± 4 |
TP142 | 1-Methyl-5′-O-trityl-β-d-ribofuranoside | ≥70 | +11 ± 17 |
TP151 | 5-Amino-1-(5′-O-trityl-β-d-ribofuranosyl)imidazole-4-[N-(2-methoxyethoxy)methyl] carboxamide | >75 | −67 ± 8 |
↵ a Number of blood vessels of untreated controls, 25.7 ± 2.9.