Genes up-regulated in the heart of zebrafish larvae 1 to 2 h after TCDD exposure
| Affymetrix ID | Genbank Accession No. | Gene Title | Log2 (TCDD/DMSO) | |||
|---|---|---|---|---|---|---|
| 1 h | 2 h | 4 h | 12 h | |||
| Cluster 1 | ||||||
| Dr0.9478.1.S1_at | NM_131879 | Cytochrome P450 1a | 3.3 | 3.9 | 2.9 | 5.5 |
| DrAffx0.2.87.S1_at | AL918492 | Cytochrome P450 1c1 | 2.2 | 4.9 | 4.5 | 5.3 |
| DrAffx0.2.86.S1_at | AY534681 | Cytochrome P450 1b1 | 3.3 | 4.1 | 4.2 | 3.4 |
| Dr0.5536.1.A1_at | BG306468 | Similar to TCDD-inducible poly(ADP-ribose) polymerase | 1.9 | 3.5 | 2.9 | 2.9 |
| Dr0.9478.2.S1_at | NM_212779 | Myeloid-specific peroxidase | 2.5 | 2.7 | 1.4 | 2.8 |
| Cluster 2 | ||||||
| Dr0.18724.1.A1_at | AI721597 | Similar to CXXC finger 5 | NC | 1.9 | 1.8 | 1.7 |
| Dr0.17164.1.A1_at | BI982814 | Similar to hypothetical protein MGC33926 | NC | 1.1 | 1.9 | 2.1 |
| Dr0.25208.1.A1_at | AY452279 | Cytochrome P450 3a65 | NC | 1.9 | 2.2 | 2.4 |
| Dr0.21790.1.A1_at | NM_212571 | Protocadherin 10a | NC | 1.8 | 2.0 | 2.5 |
| Dr0.5040.1.S1_at | BC053263 | Similar to cytochrome b5 | NC | 1.4 | 1.6 | 2.8 |
| Dr0.2499.1.S1_at | BC078421 | Myogenin | NC | 1.2 | 1.7 | 2.9 |
| Dr0.8093.1.S1_at | BC066679 | Paraxis | NC | 2.0 | 2.1 | NC |
| Dr0.9917.1.S1_at | BC047851 | Glutamate decarboxylase 1 | 1.2 | 1.8 | 1.3 | 1.2 |
| Dr0.26003.1.A1_at | CD605928 | 1.6 | 2.3 | 1.5 | 1.3 | |
| Dr0.5428.2.A1_at | NM_201143 | Similar to phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, γ) | 1.1 | 2.4 | 1.5 | 1.3 |
| Dr0.12454.1.S1_at | NM_200762 | GTP cyclohydrolase I feedback inhibitor | 1.2 | 2.3 | 1.8 | 1.5 |
| Dr0.9896.1.A1_at | BI670851 | Similar to serum/glucocorticoid kinasea | 1.5 | 2.6 | 2.1 | 1.7 |
| Dr0.13774.1.S1_at | BI703179 | Similar to sphingosine 1-phosphate receptor Edg-3a | 1.9 | 2.7 | 1.9 | 1.8 |
| Dr0.25740.1.A1_at | NM_199644 | Similar to ADP-ribosylation factor 4-like | 1.4 | 2.1 | 2.0 | 1.9 |
| Dr0.3583.1.S1_at | NM_214686 | Sulfotransferase | 1.2 | 2.2 | 2.4 | 1.9 |
| Cluster 3 | ||||||
| Dr0.25257.1.A1_at | CD014962 | Similar to enhancer-of-split and hairy-related proteina | NC | 1.9 | NC | 1.5 |
| Dr0.1917.1.A1_at | AW567374 | Max interacting protein 1 | NC | 1.2 | 1.0 | 1.3 |
| Dr0.12687.1.A1_at | AI793557 | Similar to growth arrest-specific 2 like 1 | NC | 1.2 | 1.2 | 1.1 |
| Dr0.7603.1.A1_at | NM_199980 | Similar to integral membrane protein 2C | NC | 1.4 | 1.5 | 1.1 |
| Dr0.7683.1.A1_at | BQ264112 | Similar to synaptojanin 1a | NC | 1.4 | 1.1 | 1.0 |
| Dr0.14573.2.A1_at | NM_205663 | Similar to lipoma HMGIC fusion partner | NC | 1.3 | 1.6 | NC |
| Dr0.22000.1.A1_at | AI957705 | NC | 1.0 | NC | NC | |
| Dr0.3021.2.S1_at | BQ617923 | Similar to regulator protein p122-RhoGAP | NC | 1.1 | NC | NC |
| Dr0.17890.1.S1_at | BC068370 | Similar to claudin 5 | NC | 1.1 | NC | NC |
| Dr0.11465.1.A1_at | AW777449 | Similar to HIF-prolyl hydroxylase 2 | NC | 1.2 | NC | NC |
| Dr0.8120.1.S1_at | AF159147 | Noggin 1 | NC | 1.3 | NC | NC |
| Dr0.5129.1.S1_at | NM_213519 | Similar to human sestrin 3 | NC | 1.4 | 1.0 | NC |
| Dr0.16163.1.S1_at | NM_205626 | BCL6 co-repressor | NC | 2.2 | NC | NC |
| Dr0.17146.1.A1_at | BM102517 | NC | 2.5 | NC | NC | |
| Dr0.13289.1.A1_at | BI886117 | NC | 2.0 | NC | NC | |
| Dr0.11351.1.A1_at | NM_200789 | 1.2 | 2.9 | NC | NC | |
| Cluster 7 | ||||||
| Dr0.4076.1.S1_at | NM_131519 | Endothelin 1 | 1.1 | NC | 1.3 | 1.1 |
| Dr0.431.1.S1_at | BC059551 | Hairy-related 6 | 1.1 | NC | NC | NC |
| Dr0.10713.1.S1_at | NM_131688 | ATPase, NA+/K+ transporting, α 1a0.3 polypeptide | 1.7 | NC | NC | NC |
NC, no significant change above 2-fold.
↵ a Probe blasts to 3′-untranslated region of indicated gene.