TABLE 1
The basicity of the antiestrogen side chains has only a minor impact on affinity for hERα
pKa values correspond to reported values for the corresponding secondary amine (Robertson et al., 1982). IC50 values (expressed as a percentage of the IC50 value measured for tamoxifen) measured in competitive transactivation assays or hormone binding assays in HeLa cells transfected with the wild-type hERα are the average of three or four independent experiments, respectively, and are reproducible within ± 30%.