TABLE 3

Estimation of the distance between the (E/D)RY motif in helix 3 and the various residues in helix 6 of the human β1-AR by the three-dimensional model of rhodopsin as described by Palczewski et al. (2000)

The distances were estimated from the SEGMOD-generated three-dimensional image of rhodopsin in Fig. 8.


Residue in Helix 6 of the Human β1-AR

Distance between the Indicated Residue and the α Carbon of
Asp155
Arg156
Tyr157
Å
Arg318 15.67 12.31 13.96
Glu319 14.51 11.74 14.11
Gln320 10.74 7.97 10.59
Lys321 11.98 8.61 11.04
Ala322 13.32 10.62 13.74
Leu323 10.10 8.08 11.69
Lys324 9.13 6.33 9.45
Thr325 12.74 10.08 12.95
Leu326
12.49
10.82
14.24